What Makes CoreKardia Unique?
The Science Inside the Capsule.
CoreKardia combines 16 clinically validated nutrients — each selected to support heart function across multiple biological pathways. From blood pressure regulation and cholesterol control to energy production, arterial flexibility, and inflammation reduction, every ingredient in our formula has a purpose — and the research to prove it. Explore how each nutrient contributes to total cardiovascular protection and long-term heart resilience.
🔬 Scientific References & Clinical Sources - CoreKardia is built on clinical integrity. Every claim we make is supported by published studies, health authority data, or ingredient-specific research.
1. Omega 3 Fatty Acids (EPA & DHA)
Primary Function/Benefit: Cardiovascular health, lower CVD risk, inflammation control, lipid profile optimization, hypertension management.
Key Mechanism of Action: Modulates inflammatory pathways, reduces triglyceride synthesis, and contributes to blood pressure reduction through vasodilation and anti-platelet effects.
Summarized Clinical Evidence: Elevated O3FA levels are associated with a lower incident risk for CVD. While some low-dose EPA/DHA formulations have not consistently prevented CV events in primary and secondary prevention settings, higher doses and specific formulations have shown significant benefits in reducing risk for heart attacks, CVD death, and major cardiovascular events, particularly in high-risk patients on statin therapy.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Do Fish Oils Prevent Restenosis Post-Coronary Angioplasty? | ClinicalTrials.gov, NCT00000473 | https://www.clinicaltrials.gov/study/NCT00000473 |
Pre-treatment with and ongoing use of omega-3 fatty acid ethyl esters reduce the slow-flow phenomenon and prevent in-stent restenosis in patients undergoing carotid artery stenting | Nishibe T, et al. PubMed, 2017 | https://pubmed.ncbi.nlm.nih.gov/28359716/ |
Cardiovascular Benefits of Omega-3 Fatty Acids: A Review of the Evidence | Mozaffarian D, et al. JAMA, 2016 | https://pubmed.ncbi.nlm.nih.gov/16979604/ |
A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids and Coronary Heart Disease Risk | Dominik D. Alexander. Mayo Clinic Proceedings, January 2017 | https://www.sciencedirect.com/science/article/pii/S0025619616306814 |
2. Phytosterols
Primary Function/Benefit: LDL Cholesterol Reduction & Dyslipidemia Support.
Key Mechanism of Action: Competes with cholesterol for absorption in the digestive system, leading to reduced cholesterol uptake.
Summarized Clinical Evidence: Daily intake of 2g phytosterols correlates with 8-10% lower LDL cholesterol levels. Beneficial for those on statins or ezetimibe. Studies consistently show phytosterols effectively lower LDL cholesterol levels.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease | Gylling H, et al. Atherosclerosis, 2014 | https://pubmed.ncbi.nlm.nih.gov/24468148/ |
A Randomized, Placebo-Controlled, Double-Blind Crossover Study to Assess a Unique Phytosterol Ester Formulation in Lowering LDL Cholesterol Utilizing a Novel Virtual Tracking Tool | Jones PJ, et al. PMC, 2019 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6769481/ |
Phytosterols in the Treatment of Hypercholesterolemia and Prevention of Cardiovascular Diseases | de Jong A, et al. PMC, 2017 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5729784/ |
3. Coenzyme Q10 (CoQ10)
Primary Function/Benefit: Myocardial Energy & Antioxidant Defense.
Key Mechanism of Action: Plays a vital role in mitochondrial energy production, helping the heart use energy efficiently, and acts as a potent antioxidant, protecting cells from damage.
Summarized Clinical Evidence: Used for congestive heart failure, cardiomyopathy, heart attack recovery, and hypertension. May improve congestive heart failure symptoms, contribute to lowering blood pressure, aid recovery from bypass and heart valve surgeries (when taken with other nutrients), and potentially ease statin-induced muscle weakness/pain.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Coenzyme Q10 and statin-induced myopathy: an updated review | Qu H, et al. Expert Rev Clin Pharmacol, 2018 | https://pubmed.ncbi.nlm.nih.gov/30371340/
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Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group | Mortensen SA, et al. PubMed, 1997 | https://pubmed.ncbi.nlm.nih.gov/9420639/
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Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation | Taylor F, et al. PubMed, 2022 | https://pubmed.ncbi.nlm.nih.gov/35076012/
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4. L-Arginine
Primary Function/Benefit: Nitric oxide production, endothelial health, wound healing, kidney waste removal, immune/hormone function, dilates/relaxes arteries
Key Mechanism of Action: Converts into nitric oxide (NO), a powerful neurotransmitter that helps blood vessels relax and improve circulation. Directly causes blood vessels to open wider for improved blood flow.
Summarized Clinical Evidence: May improve blood flow in coronary arteries, alleviating symptoms of clogged arteries, angina, and coronary artery disease. Decreases angina symptoms, improves exercise tolerance. Improves sexual function in ED. Reduces blood pressure in healthy people and those with hypertension. Increases blood flow in peripheral arterial disease. Reduces blood pressure in pre-eclampsia.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Oral L-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass | Marchesi E, et al. PubMed, 2009 | https://pubmed.ncbi.nlm.nih.gov/19592054/
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L-arginine supplementation in patients with cardiovascular disease: a meta-analysis of randomized controlled trials | Bai Y, et al. Am J Cardiovasc Drugs, 2009 | https://pubmed.ncbi.nlm.nih.gov/19852540/
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Arginine and Endothelial Function | Napoli C, et al. PMC, 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7460461/
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5. Magnesium Glycinate
Primary Function/Benefit: Blood pressure modulation, cardiac rhythm, prevents low magnesium levels linked to osteoporosis, high BP, clogged arteries, heart disease, diabetes, stroke
Key Mechanism of Action: Supports endothelial relaxation and muscle contraction. Corrects hypomagnesemia, which can cause inflammation, endothelial dysfunction, and insulin resistance.
Summarized Clinical Evidence: Long-term nonprescription magnesium supplement use associated with lower risk of incident HF and major adverse cardiac events in diabetes patients (benefits after 3 years). May help treat irregular heartbeat. May slightly decrease LDL/total cholesterol and increase HDL. Linked with lower risk of developing metabolic syndrome.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Magnesium for the prevention and treatment of cardiovascular disease | James J DiNicolantonio, Open Heart-2018 Jul 1 | https://pubmed.ncbi.nlm.nih.gov/30018772/
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Magnesium in hypertension, cardiovascular disease, metabolic syndrome, and other conditions: a review | Catherine M Champagne, 2008 Apr-May;23(2):142-51 | https://pubmed.ncbi.nlm.nih.gov/18390781/
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The role of magnesium in the prevention and control of hypertension | M P Ryan, 1984:16 Suppl 43:81-8 | https://pubmed.ncbi.nlm.nih.gov/6398986/
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Effects of Oral Magnesium Supplementation on Vascular Function: A Systematic Review and Meta-analysis of Randomized Controlled Trials | Bianca Cristina Antunes Alves Marques, Epub 2019 Dec 16 | https://pubmed.ncbi.nlm.nih.gov/31845310/
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Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials | Xi Zhang, Originally Published 11 July 2016 | https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.116.07664
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Magnesium and hypertension | Andrea Rosanoff, 2005 Feb;15(2):255-60 | https://pubmed.ncbi.nlm.nih.gov/15692166/
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Effectively Prescribing Oral Magnesium Therapy for Hypertension: A Categorized Systematic Review of 49 Clinical Trials | Andrea Rosanoff, 10 January 2021 | https://www.mdpi.com/2072-6643/13/1/195
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6. Hawthorn Berry Extract
Primary Function/Benefit: Cardiac energy, blood pressure modulation, improves circulation, antioxidant, heart failure, coronary artery disease, hypertension, angina, heart rhythms
Key Mechanism of Action: Improves myocardial contractility and dilates coronary vessels. Enhances heart muscle's ability to contract, increasing blood/oxygen supply to heart muscles. Contains flavonoids and OPCs that relax blood vessels and improve circulation.
Summarized Clinical Evidence: Used for centuries for cardiovascular diseases. Accumulating evidence from in vivo and in vitro studies shows antioxidant, positive inotropic, anti-inflammatory, anticardiac remodeling, and antiplatelet aggregation effects. Reviews of placebo-controlled trials report subjective and objective improvement in patients with mild heart failure (NYHA I–III), hypertension, and hyperlipidemia. A meta-analysis suggested beneficial cardiovascular effects as an adjunct to standard CHF therapy. A 2008 Cochrane review found significant benefit in symptom control and physiologic outcomes for chronic heart failure.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) Trial | Zick SM, et al. PMC, 2009 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2754502/
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Hawthorn (Crataegus spp.) in the treatment of cardiovascular disease | Mary C Tassell, Pharmacogn Rev. 2010 Jan-Jun;4(7):32–41. | https://pmc.ncbi.nlm.nih.gov/articles/PMC3249900/
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Hawthorn extract for treating chronic heart failure | Pittler MH, et al. PubMed, 2008 | https://pubmed.ncbi.nlm.nih.gov/18254076/
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7. Taurine
Primary Function/Benefit: Cardiac function, antioxidant, osmoregulation, bile acid conjugation
Key Mechanism of Action: Essential for myocardial contractility and electrical stability. Involved in osmoregulation and antioxidant defense. Modulates calcium handling in cardiomyocytes. Exhibits diverse biological actions including protection against ischemia-reperfusion injury, antioxidant, antiatherogenic, and blood pressure-lowering effects.
Summarized Clinical Evidence: Clinical trials revealed beneficial actions in various pathophysiological conditions, including heart failure (decreased left ventricular end-diastolic volume, improved cardiac function), and may protect against coronary heart disease. Animal models showed reduced hyperhomocysteinemia and atherosclerosis.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease | Xu YJ, et al. PMC, 2020 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7551180/
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Effects of taurine supplementation on blood pressure and other cardiovascular risk factors in prehypertension: a randomized, double-blind, placebo-controlled study | Sun Q, et al. Hypertension, 2016 | https://pubmed.ncbi.nlm.nih.gov/26781281/
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The potential health benefits of taurine in cardiovascular disease | Schaffer SW, et al. PMC, 2009 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2586397/
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8. Resveratrol
Primary Function/Benefit: Vascular Health & Antioxidant Protection.
Key Mechanism of Action: Works as an antioxidant fighting inflammation. Activates sirtuins, improves nitric oxide bioavailability. Exerts cardioprotective effects through modulation of antioxidant, anti-inflammatory, and anti-hypertensive pathways, and microbiota composition.
Summarized Clinical Evidence: Reduces systolic and diastolic BP in hypertension, promotes healthy blood flow, improves cholesterol, and reduces heart disease/stroke risk. Clinical trials show conflicting results on vascular biomarkers, with some showing significant reduction in SBP/DBP in type 2 diabetes and obese men, and increased FMD. Studies with food sources (red wine) showed significant effects even with lower content, while high-dose tablet supplementation often yielded null findings.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Cardiovascular Protective Effects and Clinical Applications of Resveratrol | Galiniak S, et al. PubMed, 2017 | https://pubmed.ncbi.nlm.nih.gov/28346848/
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Effects of resveratrol on blood pressure: A meta-analysis of randomized controlled trials | Liu Y, et al. Clin Nutr, 2014 | https://pubmed.ncbi.nlm.nih.gov/24731650/
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Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials | Federica Fogacci, Crit Rev Food Sci Nutr.2019;59(10):1605-1618. | https://pubmed.ncbi.nlm.nih.gov/29359958/
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Resveratrol and Cardiovascular Diseases | Bonnefont-Rousselot D, et al. PMC, 2016 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4882663/
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9. Garlic Extract (Allicin)
Primary Function/Benefit: Atherosclerosis & Blood Pressure Management.
Key Mechanism of Action: Contains allicin and other sulfur-containing compounds that prevent atherosclerosis. Its BP-lowering effect involves hydrogen sulfide and nitric oxide signaling pathways. Suppresses chronic inflammation.
Summarized Clinical Evidence: Shown to improve atherosclerosis in clinical trials and animal studies. Significantly reduced mean blood pressure (systolic 5.0±2.1 mmHg) in uncontrolled hypertensives. Tended to improve central hemodynamic measures (central BP, pulse pressure, pulse-wave velocity, arterial stiffness).
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance | Ried K, et al. PMC, 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4266250/
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Aged garlic extract and cardiovascular disease: a systematic review and meta-analysis | Ried K, et al. BMC Cardiovascular Disorders, 16 June 2008 | https://pubmed.ncbi.nlm.nih.gov/18554422/
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Effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (CAD) patients: A systematic review and meta-analysis | Sai Kumar Gadidala, Phytotherapy Research, January 2023 | https://pubmed.ncbi.nlm.nih.gov/36640154/
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Effect of aged garlic extract on blood pressure and other cardiovascular markers in hypertensive patients and its relationship with dietary intake | Tiago M.S. Vila-Nova, Journal of Functional Foods, January 2024 | https://www.sciencedirect.com/science/article/pii/S1756464623005315#ab005
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Garlic and Heart Disease | Ravi Varshney & Matthew J Budoff, February 2016 | https://jn.nutrition.org/article/S0022-3166(23)00523-0/fulltext
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Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study | Rosa M. Valls, 18 January 2022 | https://www.mdpi.com/2072-6643/14/3/405
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Effect of Garlic on Blood Pressure: A Meta‐Analysis | Wang HP, et al. PMC, 2015 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8031974/
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10. Pomegranate Extract
Primary Function/Benefit: Endothelial Protection & Blood Pressure Reduction.
Key Mechanism of Action: Potent antioxidant, enhances nitric oxide synthesis. Contains chemicals with antioxidant effects, might slow atherosclerosis progression. Punicalagins have antioxidant and anti-inflammatory properties.
Summarized Clinical Evidence: Drinking pomegranate juice reduced frequency/severity of chest pain and biomarkers in heart disease patients. Drinking juice daily can lower systolic blood pressure.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals | Saadati S, et al. PMC, 2014 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3933059/
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Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation | Aviram M, et al. Clin Nutr, 2004 | https://pubmed.ncbi.nlm.nih.gov/15158307/
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Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti-inflammatory effects of pomegranate juice in hypertensive subjects | Al-Dujaili EA, et al. PubMed, 2014 | https://pubmed.ncbi.nlm.nih.gov/23519910/
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11. Nano Curcumin
Primary Function/Benefit: Anti-inflammatory & Cardioprotective Effects.
Key Mechanism of Action: Polyphenolic compound with various pharmacological properties. Significantly alleviates vascular endothelial dysfunction, inhibits foam cell formation, reduces VSMCs proliferation, protects cardiomyocyte injury after ischemia and hypoxia, inhibits myocardial hypertrophy and fibrosis, improves ventricular remodeling, and reduces drug-induced myocardial injury.
Summarized Clinical Evidence: Clinical studies show protective effect on blood vessels. Reviews of studies confirm curcumin significantly protects against cardiomyocyte injury, inhibits myocardial hypertrophy/fibrosis, improves ventricular remodeling, reduces drug-induced myocardial injury, improves diabetic cardiomyopathy, alleviates vascular endothelial dysfunction, and inhibits foam cell formation. Newer mechanistic, animal, and human studies provide evidence that curcumin has pleiotropic effects and attenuates numerous parameters contributing to increased CVD risk.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Three months of combination therapy with nano-curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized, double-blinded, placebo-controlled clinical trial | Jamialahmadi T, et al. PubMed, 2022 | https://pubmed.ncbi.nlm.nih.gov/35674733/
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Review of the Protective Mechanism of Curcumin on Cardiovascular Disease | Li H, et al. PMC, 2021 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10838105/
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Curcumin Nanomicelle Improves Lipid Profile, Stress Oxidative Factors and Inflammatory Markers in Patients Undergoing Coronary Elective Angioplasty; A Randomized Clinical Trial | Mohammadi A, et al. PubMed, 2020 | https://pubmed.ncbi.nlm.nih.gov/33397249/
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12. Piperine
Primary Function/Benefit: Bioavailability enhancer & Anti-inflammatory.
Key Mechanism of Action: Enhances absorption and bioavailability of other nutrients, particularly curcumin, by inhibiting metabolic enzymes and increasing intestinal permeability.
Summarized Clinical Evidence: Studies demonstrate piperine significantly increases the bioavailability of curcumin (by up to 2000%) and other compounds.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
The Effects of Curcumin Plus Piperine Co-administration on Inflammation and Oxidative Stress: A Systematic Review and Meta-analysis of Randomized Controlled Trials | Sahebkar A, et al. PubMed, 2024 | https://pubmed.ncbi.nlm.nih.gov/38561618/
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A Systematic Review of Piperine as a Bioavailability Enhancer | Sanjiv Kumar Chaudhri, Journal of Drug Delivery and Therapeutics, 15.04.2023 | https://jddtonline.info/index.php/jddt/article/view/5781
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Curcumin in Combination with Piperine Suppresses Osteoclastogenesis In Vitro | Kuttan G, et al. PubMed, 2015 | https://pubmed.ncbi.nlm.nih.gov/26300429/
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13. Lycopene
Primary Function/Benefit: Antioxidant, cardiovascular health
Key Mechanism of Action: Potent antioxidant, scavenges free radicals, protects against LDL oxidation, improves endothelial function, and reduces inflammation.
Summarized Clinical Evidence: Associated with reduced risk of cardiovascular disease, improved endothelial function, and reduced oxidative stress. Clinical studies support its benefits in blood pressure modulation.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Lycopene and risk of cardiovascular diseases: A meta-analysis of observational studies | Cheng HM, et al. PubMed, 2017 | https://pubmed.ncbi.nlm.nih.gov/28318092/
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Lycopene Supplement and Blood Pressure: An Updated Meta-Analysis of Intervention Trials | 18 September 2013 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3798929/
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Lycopene Supplementation and Blood Pressure: Systematic review and meta-analyses of randomized trials | Mahnaz Rezaei kelishadi, Journal of Herbal Medicine, February 2022, 100521 | https://www.sciencedirect.com/science/article/abs/pii/S2210803321001019?via%3Dihub
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Effect of tomato, lycopene and related products on blood pressure: A systematic review and network meta-analysis | Wipharak Rattanavipanon, Phytomedicine. 2021 Jul 15 | https://pubmed.ncbi.nlm.nih.gov/33676812/
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Lycopene in the Prevention of Cardiovascular Diseases | Saini RK, et al. PMC, 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8880080/
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14. Cholecalciferol (Vitamin D3)
Primary Function/Benefit: Bone health, cardiovascular health, immune modulation
Key Mechanism of Action: Regulates calcium and phosphate homeostasis. Involved in immune function and inflammation. May influence blood pressure and endothelial function.
Summarized Clinical Evidence: Vitamin D deficiency is associated with increased cardiovascular risk. Supplementation may improve endothelial function and reduce inflammation. Note: While observational studies suggest a link, large-scale randomized controlled trials have not consistently shown a direct preventative effect of Vitamin D supplementation on major cardiovascular events.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Vitamin D in atherosclerosis and cardiovascular events | Vacek JL, et al. PubMed, 2023 | https://pubmed.ncbi.nlm.nih.gov/36943351/
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Vitamin D and Cardiovascular Disease | P.E. Norman, J.T. Powell, American Heart Journal, 17 Jan 2014 | https://www.ahajournals.org/doi/10.1161/circresaha.113.301241
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Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives | Nicola Cosentino, Nutrients 2021, 14 October 2021 | https://www.mdpi.com/2072-6643/13/10/3603
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Clinical trials of vitamin D supplementation and cardiovascular disease: A synthesis of the evidence | Scragg R. PubMed, 2025 | https://pubmed.ncbi.nlm.nih.gov/40096916/
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15. Vitamin K2 (MK-7)
Primary Function/Benefit: Arterial Calcification Inhibition & Flexibility.
Key Mechanism of Action: Activates Matrix Gla Protein (MGP), a potent inhibitor of vascular calcification. Directs calcium from arteries to bones, preventing arterial calcification. Regulates calcium deposition, promoting bone calcification and preventing blood vessel/kidney calcification.
Summarized Clinical Evidence: Plays a role in cardiovascular health, slowing progression of CAC and aortic valve calcification. Some trials showed no significant effect in mitigating calcification, but overall findings promising. Meta-analysis linked increased dietary K1/K2 intake with moderately reduced risk of coronary heart disease. Reviews note K2 shows most promise for CHD risk reduction. Daily 180 µg MK-7 for 3 years in healthy post-menopausal women improved vascular elasticity and inhibited age-related stiffening of arteries.
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial | Knapen MH, et al. PubMed, 2015 | https://pubmed.ncbi.nlm.nih.gov/25694037/
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Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health | Katarzyna Maresz, Integr Med (Encinitas). 2015 Feb;14 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4566462/
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Vitamin K2 (menaquinone) Supplementation and its Benefits in Cardiovascular Disease, Osteoporosis, and Cancer | Grant S. Buchanan, July 2016Marshall Journal of Medicine | https://mds.marshall.edu/mjm/vol2/iss3/8/
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The Role of Vitamin K2 in Cardiovascular Health | Besir Besir, Samir R. Kapadia, Review Article - Interventional Cardiology (2024) | https://www.openaccessjournals.com/articles/the-role-of-vitamin-k2-in-cardiovascular-health-18455.html
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Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial | Diederichsen A, et al. PMC, 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9047644/
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16. Folate (5-MTHF)
Primary Function/Benefit: Homocysteine Metabolism & Vascular Protection.
Key Mechanism of Action: Cofactor for homocysteine metabolism, essential for converting homocysteine to non-toxic amino acids. Involved in homocysteine metabolic pathway.
Summarized Clinical Evidence: Supplementation effectively reduces plasma homocysteine levels. Lower plasma homocysteine levels are associated with decreased risk of myocardial infarction, stroke, and venous thromboembolism. Folic acid supplementation significantly reduced first stroke, first ischemic stroke, and composite cardiovascular events in CSPPT (Chinese Stroke Primary Prevention Trial).
Study Title | Authors/Journal/Year | Study Link |
|---|---|---|
Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial | Knapen MH, et al. PubMed, 2015 | https://pubmed.ncbi.nlm.nih.gov/25694037/
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Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health | Katarzyna Maresz, Integr Med (Encinitas). 2015 Feb;14 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4566462/
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Vitamin K2 (menaquinone) Supplementation and its Benefits in Cardiovascular Disease, Osteoporosis, and Cancer | Grant S. Buchanan, July 2016Marshall Journal of Medicine | https://mds.marshall.edu/mjm/vol2/iss3/8/
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The Role of Vitamin K2 in Cardiovascular Health | Besir Besir, Samir R. Kapadia, Review Article - Interventional Cardiology (2024) | https://www.openaccessjournals.com/articles/the-role-of-vitamin-k2-in-cardiovascular-health-18455.html
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Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial | Diederichsen A, et al. PMC, 2022 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9047644/
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Your Heart Deserves the Best — Built on Science, Not Hype
CoreKardia’s formulation isn’t just a list of trendy ingredients. It’s a precise blend of clinically validated nutrients chosen to work together — across multiple pathways — to support blood pressure, cholesterol, cardiac energy, and healthy aging.
Each capsule is a result of scientific rigor, expert formulation, and a deep understanding of what your heart needs every single day.